Probing chemical space and conformational changes for subtype-selective orexin receptor antagonists.
Smith et al., 
 RSC Med Chem 2026 Aug 12;()
The orexin system, acting through OX1R and OX2R receptors, plays a key role in the regulation of sleep, motivation, and reward-related processes, making it a promising therapeutic target. While dual OXR antagonists are approved for the treatment of i...
Synergistic In Vitro Effects of Minor Phytocannabinoids and Melatonin Combinations Against Human Glioblastoma Cells.
Morelli et al., 
 Int J Mol Sci 2026 Jul 29;27(15)
The prognosis of glioblastoma (GBM) patients remains dismal due to chemoresistance. Repurposing of natural and endogenous compounds, such as the pineal hormone melatonin (MLT) and minor phytocannabinoids like cannabinol (CBN) or cannabigerol (CBG), r...
Testicular Disorders in Equids: A Case Series.
Catone et al., 
 Animals (Basel) 2026 Aug 06;16(15)
Equine testicular disorders represent a diverse group of conditions that impact the longevity of a stallion's breeding career. Stud farm veterinarians should be familiar with the variety of clinical presentations and diagnostic options for these cond...