PHAGE-BASED ANTI-HER2 VACCINATION CAN CIRCUMVENT IMMUNE TOLERANCE AGAINST BREAST CANCER.
Bartolacci et al., Cancer Immunol Res 2018 Oct 16;()
Δ16HER2 is a splice variant of HER2 and defined as the transforming isoform in HER2-positive breast cancer. It has been shown that Δ16HER2 promotes breast cancer aggressiveness and drug resistance. In the present work, we used in silico modelling t...
Gene expression profiling in adipose tissue of Sprague Dawley rats identifies olfactory receptor 984 as a potential obesity treatment target.
Giusepponi et al., Biochem. Biophys. Res. Commun. 2018 Oct 05;()
The aim of the study was to identify and functionally characterize novel candidate gene/s involved in the development of resistance to diet-induced obesity in rats. In a high-fat-diet (HFD) study of rats, we found subgroups which either developed res...
A comparison among β-caseins purified from milk of different species: Self-assembling behaviour and immunogenicity potential.
Perinelli et al., Colloids Surf B Biointerfaces 2018 Oct 01;173()
Caseins are a family of proteins constituted by α-caseins (αs-1 and αs-2 caseins), β-caseins and κ-caseins. β-caseins, in particular, show a temperature and concentration-dependent self-assembling behaviour. Recently, β-casein micelles have be...